What is 2-Phenylacetamide
2-Phenylacetamide is a monocarboxylic acid amide that is acetamide substituted by a phenyl group at position 2. It has a role as a mouse metabolite. It is functionally related to a phenylacetic acid.
Benefits of 2-Phenylacetamide
Unrivaled Quality
Our 2-Phenylacetamide stands above the rest, meeting stringent quality standards. With a remarkable product purity of 98% and a maximum moisture content of 0.5%, you can rely on its consistent performance in your pharmaceutical applications.
Crystal Form
Available in an off-white crystal form, our 2-Phenylacetamide ensures convenience and ease of use. Its robust integrity guarantees unrivaled chemical stability under a variety of conditions.
Efficient Packaging
Packaged in 25KG woven bags, this compound is designed for convenience. Its superior quality packaging preserves the product's integrity and facilitates easy handling and efficient storage.
Environmentally Friendly Manufacturing
Our 2-Phenylacetamide is produced using an environmentally friendly synthesis process. By bypassing the need for noxious reagents and minimizing the use of unnecessary additives, we promote sustainability and environmental safety.
Compliant with Global Regulations
Adhering to global quality and environmental regulations, our 2-Phenylacetamide guarantees uncompromised standards and premium chemical production.
Why Choose Us
High Quality Products
We always put customer needs and expectations in the first place, refine on, continuous improvement, to seek every opportunity to do better, to provide customers with their expectations of quality products, to provide customers with the most satisfactory service at anytime.
Quality Control
All goods will undergo strict quality inspection before shipment. MCC always insists on providing high-quality products. We firmly believe that quality is the basis of everything.
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We take great measures to ensure that we work with the industry's highest quality equipment and that our equipment is regularly and meticulously maintained.
Professional Team
We have a team of skilled and experienced professionals who are well-versed in the latest technology and industry standards. Our team is dedicated to ensuring that our customers get the best service and support possible.
Competitive Prices
We offer our products at competitive prices, making them affordable for our customers. We believe that high-quality products should not come at a premium, and we strive to make our products accessible to all.
Rich Experience
Has a long-standing reputation in the industry, which makes it stand out from its competitors. With over many years of experience, they have developed the skills necessary to meet their clients' needs.
Benzohydrazide and Phenylacetamide Scaffolds
Antibacterial resistance (ABR) is a major life-threatening problem worldwide. Rampant dissemination of ABR always exemplified the need for the discovery of novel compounds. However, to circumvent the disease, a molecular target is required, which will lead to the death of the bacteria when acted upon by a compound. One group of enzymes that have proved to be an effective target for druggable candidates is bacterial DNA topoisomerases (DNA gyrase and ParE). In our present work, phenylacetamide and benzohydrazides derivatives were screened for their antibacterial activity against a selected panel of pathogens. The tested compounds displayed significant antibacterial activity with MIC values ranging from 0.64 to 5.65 μg/mL. Amongst 29 title compounds, compounds 5 and 21 exhibited more potent and selective inhibitory activity against Escherichia coli with MIC values at 0.64 and 0.67 μg/mL, respectively, and MBC at onefold MIC. Furthermore, compounds exhibited a post-antibiotic effect of 2 h at 1× MIC in comparison to ciprofloxacin and gentamicin. These compounds also demonstrated the concentration-dependent bactericidal activity against E. coli and synergized with FDA-approved drugs. The compounds are screened for their enzyme inhibitory activity against E. coli ParE, whose IC50 values range from 0.27 to 2.80 μg/mL. Gratifyingly, compounds, namely 8 and 25 belonging to the phenylacetamide series, were found to inhibit ParE enzyme with IC50 values of 0.27 and 0.28 μg/mL, respectively. In addition, compounds were benign to Vero cells and displayed a promising selectivity index (169.0629–951.7240). Moreover, compounds 1, 7, 8, 21, 24, and 25 (IC50: <1 and Selectivity index: >200) exhibited potent activity in reducing the E. coli biofilm in comparison with ciprofloxacin, erythromycin, and ampicillin. These astonishing results suggest the potential utilization of phenylacetamide and benzohydrazides derivatives as promising ParE inhibitors for treating bacterial infections.
A method for simultaneously preparing phenylacetamide and phenylacetic acid by hydrolyzing phenylacetonitrile in ammonia-containing high-temperature liquid water medium. The method includes the following steps: 1) Add deionized water and phenylacetonitrile with a mass ratio of 2:1 to 8:1 into a high-pressure reaction kettle, stir, heat and boil, and open the exhaust valve for 2 to 5 minutes; 2) By metering Pump in 25% ammonia water to ensure that the ammonia concentration of the reactant in the kettle is 0.05~4g/L, and heat it up to 180~250℃ for hydrolysis at 5~120℃. minutes; 3) Lower the temperature and recover the ammonia gas in the kettle; 4) Cool the hydrolyzate, adjust the pH of the hydrolyzate to between 8 and 9, crystallize the hydrolyzate, and filter to obtain crude phenylacetamide; 5) Phenylacetamide The crude product is decolorized by activated carbon, secondary crystallized, and vacuum dried to obtain the phenylacetamide product; 6) Adjust the pH value of the filtrate in step 4) to between 3-4, crystallize the filtrate to obtain crude phenylacetic acid, and then pass the crude phenylacetic acid through Activated carbon is decolorized, secondary crystallized, and vacuum dried to obtain the phenylacetic acid product. The process of the invention is simple and environmentally friendly.
In the field of spices, 2-phenylacetamide is an important raw material for the synthesis of certain spices and flavors. Its unique chemical structure gives it a variety of aromas and flavors, making it a must-have in many perfumes, aromatherapy and beauty products. In the field of dyes, 2-phenylacetamide can react with certain colors in a single reaction and is an important raw material for the production of blue and purple dyes. These dyes are widely used in the textile industry, printing industry and art fields, adding rich colors to our lives. The pharmaceutical field is one of the important application fields of 2-phenylacetamide. It is an important intermediate for the preparation of a variety of antibiotics and analgesics. Common drugs such as acetaminophen and aspirin are inseparable from the participation of 2-phenylacetamide. The widespread use of these drugs plays a key role in relieving pain, reducing fever, and treating various diseases. The agricultural field is also one of the important applications of 2-phenylacetamide. It is one of the important intermediates of many pesticides such as carbamine. These pesticides play an important role in preventing and controlling pests and diseases, protecting crops, and improving crop yield and quality in agricultural production. In addition to the application fields mentioned above, 2-phenylacetamide has other chemical uses. It can be used to synthesize organic metals, organic peroxides, and organic peroxides, and provides important raw materials for chemical research and industrial production. It can also be used as a cross-linking agent in polymers to enhance the mechanical properties and stability of the material. In coating manufacturing, 2-phenylacetamide can be used as a film-forming agent to give coatings good adhesion and durability. In the plastics industry, it can also be used as a plasticizer to improve the softness and plasticity of plastics.
Synthesis of 2-Phenylacetamide
Put styrene, sulfur, liquid ammonia and water into an autoclave, react at 165°C and a pressure of about 6.5MPa, then heat and evaporate to remove hydrogen sulfide gas, add activated carbon to change color, cool, crystallize, filter, dry, Dry, dry. Acetamide. This method can be improved to assembly line continuous production. Styrene and polysulfide liquid are matched at a volume ratio of 1:2. The reaction temperature through the high-pressure pipeline is 200°C, the reaction pressure is 6-7.8MPa, and the reaction time is 1.5 hours. The post-treatment process of the reaction product is similar to the batch method of autoclave. Raw material consumption quota: styrene (99%) 1117kg/T, sulfur (98.5%) 716kg/T, liquid ammonia (99%) 539kg/T, activated carbon 47kg/T.
Another production method is heating and hydrolysis in sulfuric acid or hydrochloric acid. Add benzo to concentrated hydrochloric acid, stir to dissolve, and react at 50°C for half an hour. Then slowly add water to the crystals while cooling, filter after cooling, and wash with ice water. Wash the crude sodium carbonate solution, then with ice water. Raw material consumption quota: chloride (95%) 1190kg/T, sodium cyanide (95%) 527kg/T, ditriamine (industrial product) 20kg/T, sodium carbonate (industrial product) 185kg/T, sulfuric acid (92.5% ) 1760 kg/ton.
Solubility Behavior of 2-Phenylacetamide in Sixteen Pure Solvents and Dissolution Properties of Solution
The solid-liquid equilibrium solubility of 2-phenylacetamide in sixteen pure solvents, i.e. methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, n-pentanol, isopentanol, acetone, ethyl acetate, acetonitrile, 2-butanone, 2-pentanone, methyl acetate, ethyl formate and tetrahydrofuran was obtained over a temperature range from 273.75 K to 324.95 K by a gravimetric method under atmospheric pressure. For all the solvents investigated, the equilibrium solubility of 2-phenylacetamide increases with augmented temperature. The statistical correlations were correlated by the modified Apelblat model, λh equation, non-random two-liquid (NRTL) equation and the Wilson equation. On the basis of thermodynamic relations and the Wilson model, the dissolution enthalpy, entropy, and Gibbs free energy were calculated. The results demonstrate that the dissolution of 2-phenylacetamide is a spontaneous and entropy-driven process in the selected solvents. The solubility data, correlation models and derived dissolution properties would promote the development of the separation and reaction of 2-phenylacetamide in industry.
Alkylation of N-Substituted 2-Phenylacetamides
Various N-substituted phenylacetamides were alkylated using different alkylating agents under neutral and basic conditions. Reactions were performed at different reaction temperatures and in various solvents. Also, a number of various catalysts were used including phase-transfer catalysts. Reactions were followed using GC or GC-MS technique and the presence as well as the yields of the alkylation products were established. Generally, the best yield and high selectivity in the studied reactions were achieved under basic conditions where in the certain cases some products, mostly N-product, were obtained solely in quantitative yields.
What Are the Physical Properties of 2-Phenylacetamide, Such as Its Melting Point and Boiling Point
Chemical & Physical Properties
|
Density |
1.1±0.1 g/cm3 |
|
Boiling Point |
312.2±21.0 °C at 760 mmHg |
|
Melting Point |
156 °C |
|
Molecular Formula |
C8H9NO |
|
Molecular Weight |
135.163 |
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